The acknowledged affect of these PTMs on ATXN2’s functionality and SCA2 pathogenesis stays limited. In other polyQ ailments, multiple scientific studies proposed that proteolytic cleavage of polyQ proteins could Engage in an essential position in pathogenesis [36, 45]. Aligned using this type of idea, the presence of the enriched 42 kDa https://karelj766ykv9.wikibestproducts.com/user