Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis. 1. Cytokine binding induces or re-orients receptor dimerization, this sort of that JAK kinase domains deal with each other within a effective conformation for transactivation and phosphorylation on the cytokine receptor cytoplasmic tails Intriguingly, it has been https://ermao520fkp3.bloggactivo.com/profile