There exists a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors while in the dorsal horn to decrease afferent pain transmission and make analgesia. For that reason, medication like clonidine that goal alpha-two receptors can affect the transmission of discomfort. Applies to clonidine: oral https://omara961umc8.wikinarration.com/user