Background/Aims Besifovir dipivoxil maleate (BSV). an acyclic nucleotide phosphonate. shows potent antiviral activity against hepatitis B virus. Our previous 48-week trial revealed that BSV has comparable antiviral efficacy to tenofovir disoproxil fumarate (TDF) and better safety profiles in terms of improved renal and bone safety. https://www.hacklinkci.com/