Exploration into conolidine has brought about discovery of the opioid receptor in the human body named ACKR3/CXCR7. ACKR3 is apparently one of the most wanted goal for conolidine, which also disregards another 4 classical opioid receptors(three). There may be interest in employing conolidine like a pain-reliever depending on evidence https://thefairlist.com/story11034173/not-known-factual-statements-about-conoldine-alternative-natural-pain-relief